Matthew John Guille Portrait

Professor Matt Guille

Professor of Developmental Genetics

Matthew.Guille@port.ac.uk

PhD Supervisor

View my research outputs
Faculty of Science and Health School of the Environment and Life Sciences Biological sciences Pharmacy, pharmacology, and biomedical sciences Health and wellbeing Epigenetics and Developmental Biology Research Group

Biography

I did my degree and PhD in Biochemistry at King’s College London, where I first worked on Xenopus. I went on to post-doc fellowships working on gene regulation at CRUK and the Developmental Biology Research Centre, both in London. From there I moved to 91¸£ÀûÍø setting up an independent lab working on gene regulation in Xenopus and in 2006 led the inception of the European Xenopus Resource Centre funded by the Wellcome Trust. Having 91¸£ÀûÍø as a hub for the latest developmental biology research makes it a very exciting place for me to study and, after doing my five year turn as head of school, I am currently enjoying working hands on alongside my team in the lab.

Alongside my Xenopus work I enjoy collaborating with the Marine Biologists in 91¸£ÀûÍø to support their use of the latest molecular genetics technologies in fascinating applied research projects.

For more information about my research please visit my .

Research interests

My team researches gene regulation in the early development of the Xenopus (clawed frog) embryo. This includes transcription factor regulation (Brzostowski et al, 2000, Cazanove et al 2008) and epigenetic mechanisms (Steer et al 2003, Abu-Daya et al, 2005). Currently we are performing a systematic analysis of the function and control of the variant histones in early development in collaboration with Dr Fiona Myers. Half of MJG’s time is dedicated to running the European Xenopus Resource Centre (EXRC), in this context developing improved techniques for working with Xenopus (Love et al 2012) and enhancing frog welfare (Abu-Daya et al 2012).

  • Transcription factor activity control in the early embryo
  • dsRBD containing proteins
  • Chromatin regulation in the early embryo
  • The genetics of wood digestion in the marine environment
  • Developing new tools for the Xenopus model

Research outputs

2025

Seaby, E. G., Godwin, A., Meyer-Dilhet, G., Clerc, V., Grand, X., Fletcher, T., Monteiro, L., Kerkhofs, M., Carelli, V., Palombo, F., Seri, M., Olivucci, G., Grippa, M., Ciaccio, C., D’Arrigo, S., Iascone, M., Bermudez, M., Fischer, J., Di Donato, N., Goesswein, S., Leung, M. L., Koboldt, D. C., Myers, C., Arnadottir, G. A., Stefansson, K., Sulem, P., Goldberg, E. M., Bruel, A., Tran Mau Them, F., Willems, M., Bjornsson, H. T., Hognason, H. B., Thorolfsdottir, E. T., Agolini, E., Novelli, A., Zampino, G., Onesimo, R., Lachlan, K., Baralle, D., Rehm, H. L., O’Donnell-Luria, A., Courchet, J., Guille, M., Bourgeois, C. F., Ennis, S.

6 Feb 2025, In: Brain, 14p.

Research output: Article

2024

Willsey, H. R., Seaby, E. G., Godwin, A., Ennis, S., Guille, M., Grainger, R. M.

4 Jun 2024, In: Disease Models & Mechanisms. 17, 5, p. 1-12, 12p.

Research output: Article

Kaiyrzhanov, R., Rad, A., Lin, S., Bertoli-Avella, A., Kallemeijn, W. W., Godwin, A., Zaki, M. S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Karimiani, E. G., Hempel, M., Normand, E. A., Rudnik-Schöneborn, S., Schatz, U. A., Baggelaar, M. P., Ilyas, M., Sultan, T., Alvi, J. R., Ganieva, M., Fowler, B., Aanicai, R., Tayfun, G. A., Al saman, A., Alswaid, A., Amiri, N., Asilova, N., Shotelersuk, V., Yeetong, P., Azam, M., Babaei, M., Monajemi, G. B., Mohammadi, P., Samie, S., Banu, S. H., Basto, J. P., Kortüm, F., Bauer, M., Bauer, P., Beetz, C., Garshasbi, M., Issa, A. H., Eyaid, W., Ahmed, H., Hashemi, N., Hassanpour, K., Herman, I., Ibrohimov, S., Abdul-Majeed, B. A., Imdad, M., Isrofilov, M., Kaiyal, Q., Khan, S., Kirmse, B., Koster, J., Marques Lourenço, C., Mitani, T., Moldovan, O., Murphy, D., Najafi, M., Pehlivan, D., Rocha, M. E., Salpietro, V., Schmidts, M., Shalata, A., Mahroum, M., Talbeya, J. K., Taylor, R. W., Vazquez, D., Vetro, A., Waterham, H. R., Zaman, M., Schrader, T. A., Chung, W. K., Guerrini, R., Lupski, J. R., Gleeson, J., Suri, M., Jamshidi, Y., Bhatia, K. P., Vona, B., Severino, M., Schrader, M., Guille, M., Tate, E. W., Varshney, G. K., Houlden, H., Maroofian, R.

1 Apr 2024, In: Brain. 147, 4, p. 1436–1456

Research output: Article

2023

Alles, N., Guille, M., Górecki, D. C.

1 Mar 2023, In: Developmental Dynamics. 252, 3, p. 429-438, 10p.

Research output: Article

2022

Ismail, V., Grønborg Dorvil, L., Godwin, A., Sahakian, M., Ellard, S., Stals, K. L., Tatton-Brown, K., Foulds, N. C., Wheway, G., Parker, M., Lyngby, S. M., Pedersen, M. G., Desir, J., Bayat, A., Musgaard, M., Guille, M., Skov Kristensen, A., Baralle, D.

7 Jul 2022, In: American Journal of Human Genetics. 109, 7, p. 1217-1241

Research output: Article

Godden, A. M., Antonaci, M., Ward, N. J., van der Lee, M., Abu Daya, A., Guille, M., Wheeler, G.

1 Mar 2022, In: Developmental Biology. 483, 10p.

Research output: Article

Tuncay, A., Noble, A., Guille, M., Cobley, J. N.

1 Mar 2022, In: Free Radical Biology and Medicine. 181

Research output: Article

2021

Noble, A., Guille, M., Cobley, J. N.

1 Oct 2021, In: Free Radical Biology and Medicine. 174, 9p.

Research output: Article

Moreno, M. M., Barrell, W. B., Godwin, A., Guille, M., Liu, K. J.

1 Jun 2021, In: Gene Expression Patterns. 40, 10p., 119183

Research output: Article

Macken, W. L., Godwin, A., Wheway, G., Stals, K., Nazlamova, L., Ellard, S., Alfares, A., Aloraini, T., AlSubaie, L., Alfadhel, M., Alajaji, S., Wai, H. A., Self, J., Douglas, A. G., Kao, A. P., Guille, M., Baralle, D.

25 Feb 2021, In: Genome Medicine. 13, 1, p. 1-19, 19p., 34

Research output: Article