Paul Cox Portrait

Professor Paul Cox

Professor of Materials Chemistry

Paul.Cox@port.ac.uk

PhD Supervisor

View my research outputs
Faculty of Science and Health School of Medicine, Pharmacy and Biomedical Sciences Pharmacy, pharmacology, and biomedical sciences

Biography

UResearch Activity

My work focuses on the application of molecular modelling methods to a wide range of chemical and biological areas.  I am the director of the University's Centre for Molecular Design (CMD).  We work closely with both both internal and external research groups to provide modelling work in support of experimental studies.  The CMD is also an important part of the University's Centre for Enzyme Innovation.

Key Research Topics

1.  Catalysis

We use computer simulations to help solve the structure of complex catalytic materials.  Notable examples of success include our work on NU-87 and STA-20.  Computational methods have also been used to look at the relationshiip between different zeolite structures and the SDAs (Structure Directing Agents) that have been used in their synthesis.  By improving our fundamental understanding of this relationship we have been successful in designing new SDAs for new targets.

2.  Microporous Materials and Drug Delivery

A combination of theroy and experiment is being used to optimise the use of mesoporous and microporous materials for controlled release.  One key goal is the identification of the best material to use for the delivery of a particular drug.

3.  Modelling Proteins and Enzymes

A range of modelling techniques have been used to investigate the structure and properties of enzymes and proteins.  Docking methods are also used to identify new drug molecules for candidate structures.

 

Research interests

  • Molecular modelling
  • Quantum mechanics
  • Solid-State chemistry

Research outputs

2025

Lozinska, M. M., Chitac, R. G., Bruce, E., Manoj, M., Du, Y., Dawson, D., Ashbrook, S., Cox, P., Wright, P. A.

3 Apr 2025, In: Chemistry, 11p., e202500327

Research output: Article

2024

Kuatsjah, E., Schwartz, A., Zahn, M., Tornesakis, K., Kellermyer, Z., Ingraham, M., Woodworth, S. P., Ramirez, K., Cox, P., Pickford, A., Salvach繳a, D.

24 Dec 2024, In: Cell Reports. 43, 20p., 115002

Research output: Article

Clark, M., Tornesakis, K., K繹nig, G., Zahn, M., Lichtenstein, B. R., Pickford, A. R., Cox, P. A.

5 Nov 2024, In: ACS Omega. 9, 44, p. 44724-44733, 10p.

Research output: Article

Gonz獺lez-Camu簽as, N., Cant穩n, ., Dawson, D. M., Lozinska, M. M., Mart穩nez-Triguero, J., Mattock, J., Cox, P. A., Ashbrook, S. E., Wright, P. A., Rey, F.

13 May 2024, In: Journal of Materials Chemistry A

Research output: Article

Co, V. A., El-Nezami, H., Liu, Y., Twum, B., Dey, P., Cox, P. A., Joseph, S., Agbodjan-Dossou, R., Sabzichi, M., Draheim, R., Wan, M. L. Y.

8 Mar 2024, In: ACS Pharmacology & Translational Science. 7, 3, p. 863-877

Research output: Article

2023

Potter, M. E., Amsler, J., Spiske, L., Plessow, P. N., Asare, T., Carravetta, M., Raja, R., Cox, P. A., Studt, F., Armstrong, L.

5 May 2023, In: ACS Catalysis. 13, 9, p. 5955-5968

Research output: Article

Chitac, R. G., Shannon, M. D., Cox, P. A., Mattock, J., Wright, P. A., Turrina, A.

24 Jan 2023,

Research output: Chapter (peer-reviewed)

2022

Erickson, E., Gado, J. E., Avilan, L., Bratti, F., Brizendine, R. K., Cox, P., Gill, R., Graham, R., Kim, D., Koenig, G., Michener, W. E., Poudel, S., Ramirez, K. J., Shakespeare, T. J., Zahn, M., Boyd, E. S., Payne, C., DuBois, J. L., Pickford, A. R., Beckham, G. T., McGeehan, J.

21 Dec 2022, In: Nature Communications. 13, 1, 15p., 7850

Research output: Article

Lozinska, M. M., Bruce, E. L., Mattock, J., Chitac, R. G., Cox, P. A., Turrina, A., Wright, P. A.

7 Oct 2022, In: Chemistry. 28, 56, 8p., e202201689

Research output: Article

2021

Verbraeken, M. C., Mennitto, R., Georgieva, V. M., Bruce, E. L., Greenaway, A. G., Cox, P. A., Min, J. G., Hong, S. B., Wright, P. A., Brandani, S.

1 Feb 2021, In: Separation and Purification Technology. 256, 117846

Research output: Article